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HelpTest Code VALPG Valproic Acid, Free and Total, Serum
Reporting Name
Valproic Acid, Free and Total, SUseful For
Monitoring both total and free valproic acid levels in therapy
Assessing compliance
Evaluating potential toxicity
Method Name
VALPA: Immunoassay
VALPF: Ultrafiltration Followed by Immunoassay
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions:
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.
Reject Due To
| Gross hemolysis | Reject |
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reference Values
VALPROIC ACID, TOTAL
Therapeutic: 50 (trough)-125 (peak) mcg/mL
Critical value: ≥151 mcg/mL
VALPROIC ACID, FREE
Therapeutic: 5-25 mcg/mL
Critical value: >30 mcg/mL
Day(s) Performed
Monday through Sunday
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
VALPA-80164
VALPF-80165
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VALPG | Valproic Acid, Free and Total, S | 57775-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| VALPF | Valproic Acid, Free, S | 4087-3 |
| VALPA | Valproic Acid, Tot, S | 4086-5 |
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| VALPF | Valproic Acid, Free, S | Yes | Yes |
| VALPA | Valproic Acid, Tot, S | Yes | Yes |
Report Available
Same day/1 dayForms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.